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Ottestad-Hansen et al., 2018)

Enrichment of fatty acid and amino acid metabolism pathways suggests that iPSC-derived neurons rely less on glucose oxidation and more on other alternative substrates to fuel OXPHOS

The overproduction or impaired clearance of A that results in an excessive A buildup is referred to as amyloidogenesis

In studies investigating the effects of morroniside on cytotoxicity induced by hydrogen peroxide in human neuroblastoma tumor SH-SY5Y cells, it was observed that morroniside effectively reduced intracellular calcium accumulation, mitigated hydrogen peroxide-induced mitochondrial membrane potential (MMP) disruption, and decreased the percentage of apoptosis triggered by hydrogen peroxide (84)

Hepatic cancer has not been investigated systematically in any of these trials, but in two of them it has been reported as cause of death, and/or found at biopsy or at autopsy (silymarin = 3.1 %, placebo = 4.5 %, and silymarin = 3.4 %, placebo = 7.1 %, respectively) [115, 116]