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There are several possible mechanisms whereby a reduced selenium status with associated lower GSH-Px activity may contribute to the pathogenesis of asthma

A total of 14 current investigational agents target proteostasis ( Table 2) by attempting to reduce mutated proteins prone to aggregation or enhancing cellular mechanisms to clear aggregates [212]

However, the inherent heterogeneity of tumors and their immune microenvironment complicates its role in tumor suppression

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