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The cardinal manifestations of PD commonly include motor impairments such as tremors, bradykinesia, rigidity, and postural instability

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For instance, although a large number of studies have shown that metformin treatment can reduce inflammation, delay disease progression and protect bone tissue in the RA progression, few studies focus on the relationship between metformin treatment and the risk of RA (5)

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However, inconsistent findings on glutamate dehydrogenase have reported in post-mortem analyses of brains from schizophrenia patients [113,114,115]