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Thus, even though AhpF can obtain electrons from NADH, based on the relatively low availability of NADH in cells, the suppressor mutant of AhpC is likely fueled predominantly by NADPH

For example, one study showed that in people with type 2 diabetes, treatment with semaglutide (1 mg weekly) causes an average loss of about 6% of body weight over 40 weeks, while treatment with tirzepatide (15 mg/week) leads to an 11% weight loss in this population