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We hypothesize the outcomes of NASH cirrhosis are will be related to IHHA as measured by PHM

Trends Biochem Sci 35: 4352 Rutherford JC, Jaron S, Winge DR (2003) Aft1p and Aft2p mediate ironresponsive gene expression in yeast through related promoter elements

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However, once it enters cancer cells, once inside cancer cells, high intracellular GSH concentrations cleave the disulfide bond, converting the cyclic peptide into its linear form