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Macrophages play a pivotal role in the inflammatory process, and upon activation by LPS, they generate significant quantities of pro-inflammatory cytokines

Tukey post-hoc tests showed a significant increase in the number of Iba1, GFAP, NF-kB, caspase3, and HO-1 positive cells with a significant reduction in the number of NeuN and Nrf2 positive cells in the diabetic group as compared to the negative control group

These can include temporary digestive changes, mild headaches (which are often linked to hydration or electrolyte balance), and some muscle soreness as your body adapts to increased fat oxidation