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Results Ant2 / leads to T-cell lymphopenia due to failure to respond to homeostatic expansion signals To test the impact of depleting mitochondrial ATP from T cells, we generated T-cell-specific Ant2 / mice by crossbreeding Ant2 flox/flox mice with distal Lck-cre transgenic mice (dLck-Cre + )

In the absence of adequate levels of Zn, programmed cell death (apoptosis) is potentiated (79)

Pogrmic et al., 2009

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Full geometry optimizations, relaxed scans and transition structure searches were carried out with Gaussian 16 83 with the ONIOM 84 QM/MM method using the B3LYP hybrid functional 85 and 6-31 G(d) basis set with ultrafine integration grids for the QM part and the ff14SB 78 , gaff2 79 and TIP3P 86 force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding