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The sarcoplasmic/endoplasmic reticulum calcium ATPases (SERCAs) move calcium ions into the ER, while plasma membrane Ca 2+ ATPases (PMCAs) transport calcium ions out of the cell

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It has been shown that low serum vitamin B 12 is associated with a 2- to 4-fold higher risk of cognitive impairment.50 The prevalence of low serum vitamin B 12 has been reported to be significantly higher in the people with Alzheimers disease (AD).52 However, the causal relationship between vitamin B 12 deficiency and the development of AD remains controversial