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doi: 10.1016/j.cell.2006.01.007 94 MaR-YBlackAQianB-Z

The effect is reproducible but typically not dose-defining relative to other covariates (e.g., albumin, tumor burden, time varying clearance)

They have many beneficial traits that make them appealing, such as high stability for long-term storage, easy synthesis for efficient production, and better drug absorption than traditional formulations [164, 165]

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In contrast, a study involved in 614 Brazilian cases reported that higher serum concentrations of vitamin B12 were positively associated with the severity of fibrosis and steatosis (20)