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Surprisingly, a few animals presented with classic hindlimb weakness and paralysis akin to those observed in other models of ALS (Supplemental Video 1)

In that trial, to reach this goal, high NAC doses were administered to patients with the registration of gastrointestinal adverse events and a considerable variability in aqueous and plasma NAC, probably only because of its relatively low absorption and bioavailability [13]

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10.1002/hep.27242 195 SmeuninxB.BoslemE.FebbraioM