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Kanehisa M, Goto S

Methods: Study design: Multicentre cluster RCT with included health economic and process evaluations Study setting: Ambulance services, local stroke units and CSCs in England Cluster randomisation: Ambulance stations or teams Intervention: Specialist pre-hospital redirection pathway involving semi-structured telephone communication of information from ambulance to CSC clinicians, who then recommend admission destination according to the likelihood of treatable LVO being present Control: Standard care Study population: All suspected and confirmed stroke in participating regions Participant enrolment: Waiver of consent Co-primary outcome: Thrombectomy rate and time to treatment Secondary outcomes: Key aspects of emergency care including time intervals and receipt of other treatments including thrombolysis Sample size: Powered on a primary analysis population(ischaemic stroke), 564 thrombectomy procedures will detect at least 30-minutes difference in time to treatment

Property NAD+ (Nicotinamide Adenine Dinucleotide) MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) 5-Amino-1MQ (5-Amino-1-methylquinolinium) Molecular Formula CHNOP CHNOS CHN Molecular Weight 663.43 g/mol 2174.6 g/mol 159.21 g/mol PubChem CID 925 255386757 950107 CAS Number 53-84-9 1627580-64-6 42464-96-0 Synonyms -Nicotinamide adenine dinucleotide, DPN, Coenzyme I, Diphosphopyridine nucleotide Human MOTS-c, UNII-A5CV6JFB78, MOTS-c trifluoroacetate salt 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZMJBCEIHNOWCMC-UHFFFAOYSA-O, STL196667

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Neurological and Cognitive Benefits Protects neurons from oxidative and ischemic injury