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Description

Experimental observations are intended exclusively for scientific exploration and hypothesis development within regulated research environments

Caraballo JC, Yshii C, Westphal W, Moninger T, Comellas AP

Activated T cells without GPX4 accumulate cellular lipid peroxides and undergo ferroptosis (21, 39, 40), while ferroptotic oxidative signals are produced primarily by iron-mediated Fenton reaction or enzymatic reaction via lipoxygenases or the dysregulated GSH antioxidant system (41, 42)