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While the mechanisms underlying amyotrophic lateral sclerosis remain elusive, considerable evidence suggests that an overproduction of ROS, coupled with a deficient antioxidant defense system, represents a significant pathological characteristic of the disease (Cunha-Oliveira et al., 2020[105])

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A relatively high concentration of [ 35 S] MSM was detected in the blood, spleen, and hair tissues, and the administered MSM might have been metabolized to yield certain sulfur-containing compounds, such as keratin, a key component of hair and nail in rats (Otsuki et al., 2002)

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There is therefore a need for a more bioavailable solution