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Norepinephrine reuptake inhibition: Increases metabolic rate (thermogenesis) Enhances fat oxidation Suppresses appetite centrally Increases energy expenditure Also increases heart rate and blood pressure (side effects) 3

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The findings that SG and RYGB similarly affect alcohol pharmacokinetics align with the results from several (236, 259, 260) but not all (261, 262) studies, suggesting a comparable increase in AUD prevalence following both procedures