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In contrast, iCMS2 tumors were predominantly microsatellite-stable (MSS), left-sided, and characterized by high MYC and WNT pathway activity, frequent APC and TP53 mutations, low immune infiltration, and gene expression signatures associated with increased sensitivity to chemotherapy and anti-EGFR therapy

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Neurons are exquisitely sensitive to oxidative stress and require high levels of NADPH to generate antioxidant defense systems regulated by GSH and Trx

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doi: 10.1002/jmv.26716 68 DominariA.Hathaway IiiD.KapasiA.PaulT.MakkarS

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