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VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure

As an enzymatic cofactor in the synthesis of monoamine neurotransmitters, including serotonin and dopamine, reduced BH4 levels contribute to decreased 5-Hydroxytryptamine (5-HT) and dopamine (DA) levels, which induces depressive-like behaviors (Nasser et al., 2014

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