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Immunopathogenesis of IBD: current state of the art

However, most experts agree that this is well below the physiological needs of most individuals

BMC Cancer 12, 421

Hyodo, K., Hashimoto, K., Kuchitsu, K., Suzuki, N

Without sufficient Tregs, the immune system may become skewed towards a Th2-dominant profile, which is associated with allergic responses and impaired mucosal tolerance [152,153,154]