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PMID: 40909720 bioRxiv Modeling acquired TKI resistance and effective combination therapeutic strategies in murine RET+ lung adenocarcinoma

doi: 10.1016/j.cyto.2011.10.001 43 LiuR

Antioxidant Defense and Oxidative Stress Glutathione is your bodys primary shield against oxidative stress

Concurrent extracellular acidosis resulting from anaerobic glycolysis and impaired perfusion reduces uptake of weakly basic chemotherapeutics through pH-dependent ion trapping, further limiting drug efficacy (135, 136)