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Akkus E, Ozkara H, Alici B et al: Incision and venous patch graft in the surgical treatment of penile curvature in Peyronie's disease

PubMed Research indicates that neutral pH (7.4) formulations increase niacinamide skin permeation approximately twofold compared to acidic pH (5.0), with corresponding changes in stratum corneum electrical properties facilitating enhanced transdermal delivery