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Mol Cell Endocrinol 458:615

Generally, patients might start to notice subtle changes within a few weeks, with more significant weight loss results often taking several months

The current state of knowledge cannot answer questions such as the threshold level of oxidative stress necessary to activate tumor development, the types of ROS that promote tumorigenic/antitumorigenic signaling, critical subcellular localizations where oxidative stress peaks, and other factors

Timing of the test relative to meals generally does not significantly impact results, as B12 is measured in serum rather than immediately after absorption