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Other drug options include Amantadine to help with tremors, Catechol-O-methyl transferase (COMT) inhibitors to prevent COMT from deactivating levodopa, Anticholinergic drugs to reduce tremors by blocking the neurotransmitter acetylcholine, and Adenosine A2A receptor antagonists, which can work in a similar manner to levodopa to reduce symptoms during levodopa off times

PubMed CrossRef Saitz R, Ghali WA, Moskowitz MA

These are rare at the doses used in supervised clinical care and when they occur, they're typically mild and transient

Current research is still in its early stages, and more studies are required to fully assess its safety and long-term effects

Then the animals received an intraperitoneal injection of saline (100 mL/kg) and were placed in individual cages for recovery