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H.MoreauP.TouzeauC.FaconT.et al (2021)

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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

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At the same time, this should be accompanied by systematic assays to quantify the protection conferred by intervention strategies aimed at gut microbiota (e.g., inhibiting TMA-producing bacteria), targeting the TMA-TMAO metabolic axis or direct scavenge of TMAO on chondrocyte ferroptosis and OA progression