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loser cells triggered by oxidative stress response rely on adaptive regulation of the Nrf2 pathway to maintain cellular homeostasis, but excessive accumulation of Nrf2 in loser cells relies on JNK to induce cell death (285), highlighting the importance of balance in the process of cell development and normal function and illustrating that both excessive and insufficient responses can have detrimental effects

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& Wlodawer, A

UV irradiation was carried out once every 2 days, namely

also found that 34% of injuries recur in the same season