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MAT1A is expressed mainly in liver cells and encodes the catalytic subunit 1 (MAT1a), which forms MATI (homo-tetramer) and MATIII (homo-dimer) ( MAT2A and MAT2B are expressed in all tissues, encoding the catalytic subunit 2 (MAT2a) and the regulatory subunit (MAT2b), respectively ( MAT2A while downregulating the expression of MAT2B ( Figure 1 )

However, the pathogenesis of AD is much more complex and oxidative stress may play a patho-physiological role (Sultana and Butterfield 2010)

Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids

doi: 10.4103/ijpvm.IJPVM_576_17 13 HagerMNouriKImhofMEgarterCOttJ

10.1016/j.bbagen.2009.03.002 260