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Functional enrichment showed that KEGG and GO (BP) were both focused on the cell cycle (Fig

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Finally, H 2 O 2 levels were significantly increased in cultured G6PDH-null chondrocytes but only during differentiation in hypoxia, indicating that the decreased NADPH:NADP + and GSH:GSSG ratios can still prevent oxidative stress during proliferation but not during differentiation, probably because redox balance is more challenged during differentiation (Fig

On the other hand, the intrinsic apoptosis pathway mainly consists on the stimulation of apoptosis by intracellular stimuli that may occur by irreparable cellular damage or cells being hijacked by pathogens (Lamkanfi and Dixit, 2010)