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454,455,456 The upregulation of NAMPT by the activation of the HIF1- pathway under hypoxic conditions plays a vital role in processing dietary lipids to regulate the plasticity of adipose tissue, whole-body glucose homeostasis and food intake

It is a complex process controlled by angiogenic and angiostatic molecules resulting in ideal revascularization of the wound bed, and providing oxygen, nutrients, and inflammatory cells to the newly growing/regenerating as well as tumor tissue (20, 21)

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