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the 2.88 mg/kg amount produced the larger effect on neuroinflammatory cytokine markers and PI3K/AKT pathway activation [5]

As expected, P28A and P29A mutations did not show a significant change in pK I affinity values for amylin receptor 1 ECD binding, while S34A mutation significantly increased the backbone peptide affinity by 2.5-fold (Figure 2D and Table 2)