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191 Treatment with sodium fluoride and bisphosphonates have been considered, but have demonstrated little to no benefit

The VOSviewer co-occurrence network (Figure 2) revealed 157 keywords across the selected articles, with the most frequent being fatty acids, antioxidants, and epidermis, reflecting core research themes

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The electrophile 4-HNE has been widely studied as a signaling molecule that stimulates the cell cycle and cell proliferation and as a cytotoxic molecule that inhibits gene expression and promotes the development of disease [19]

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