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When iron metabolism is disordered or ATG expression is abnormal, iron autophagy mediated by NCOA4 can induce ferroptosis by degrading ferritin and inducing iron overload ( Hypoxia can also affect iron metabolism

PMID: 32044413

Chronic alcohol ingestion decreases intestinal REG3G expression, which is negatively associated with the number of mucosa-associated bacteria in both human patients and experimental mouse models