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Proc Natl Acad Sci USA 99:30473051

Brunner EJ

Epigenetic modifications, including DNA methylation and histone acetylation, influence the DNA damage response (DDR)

Notably, this regulatory patternvia the apolipoprotein L3 (APOL3)-lactate dehydrogenase A (LDHA) axisreduces intracellular lactic acid levels and enhances CD8 + T cell cytotoxicity, which may eventually lead to their direct triggering of ferroptosis in target tumor cells