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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats

BMJ 2010;340:c2181

As circulating CORT levels rise, its cytotoxic effects intensify, exacerbating internal inflammation and triggering cellular autonomous death processes, impairing tissue function

We confirmed that lowering of Fas (activity) was beneficial to OLs since addition of Fas inhibitor C75 led to an increased differentiation in DA Wt but not in DA Gsta4 OLs

9,10 Myeloperoxidase and cyclooxygenase-1 are enzymes that also function in the processing of NAPQI into non-reactive metabolites