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A significant finding was the dysregulation of purine metabolism, a pathway that plays dual roles in maintaining intracellular energy homeostasis and mediating extracellular purinergic signaling

This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

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In addition, collagen has been shown to help relieve joint pain in older adults and promote faster wound healing