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The result of this metabolic reprogramming is that mitochondria contribute with biosynthetic intermediates for membrane synthesis and DNA formation, allowing NADPH availability

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We cotransfected WT-Drp1, 4KR-N, 4KR-C or 8KR with a plasmid overexpressing MAPL into NPCs and performed co-IP assays to detect the SUMO1 modification of Drp1

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Transcription activator AP-1 (a heterodimer consisting of c-Fos and c-Jun) and Nrf2 are also redox-sensitive transcription factors, which are closely related to the pathogenesis of RA (214)

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