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Vitamin B 12 (cobalamin) is required for protecting mitochondrial function and neuronal signaling

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Furthermore, iron deficits have been specifically related to severe dopaminergic dysfunction in animal models, either by constraining systemic iron intake 21,22,23,65 or by suppressing neuronal iron uptake 24

This suggests that CD63-mediated packaging at endosomes may result in protein degradation or misfolding, given that endosomes serve as sites for protein degradation