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J., Orlebeke, J

doi: 10.1016/j.freeradbiomed.2023.06.004 128 MohammadiSAl-HarrasiA

LNPs are most commonly manufactured using the microfluidic mixing technology in which the four lipid components (in organic phase) are rapidly mixed with the RNA solution (in aqueous phase) in the microfluidic mixer to form the resultant LNPs via self-assembly (Figure 1)