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2.20 Statistical analysis Statistical analysis was performed using SPSS 26.0 and R 4.2.1

Free radicals still have a role to play in the body, however an excess depletes glutathione levels and leads to oxidative stress , Dr

Furthermore, compared to directly targeting LDHA, metabolic interventions aimed at upstream glycolytic regulators may elicit broader biological effects and potential unpredictability ( The aforementioned upstream intervention strategies targeting lactate production and transport offer the advantage of simultaneously reversing microenvironmental acidification and inhibiting lactylation modifications, thereby achieving dual antitumor effects

Pro-inflammatory factors like TNF- and IL-1 upregulate inflammation-related genes through NF-B pathway activation (280)

Similarly, another clinical trial tested the effect of Glutathione on skin color and other related skin conditions, and the study showed positive results on the potential of Glutathione in the above-stated field