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Phase IIb study of intranasal glutathione in Parkinsons disease

Nutlin-3, an inhibitor of the double-minute 2 homolog, increases p53 stability and maintains cellular GSH levels through a p53-21-dependent pathway, promoting cell survival under metabolic stress such as cystine loss [61]

Time dependence of inhibition TGR was incubated at room temperature (up to 6 h) and at 4 C for 6 to 24 h with 50 M inhibitor and 100 M NADPH for the indicated times