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Plasma values as measure for tissue function On the indicated time points, whole blood samples were collected in a Microvette with Lithium Heparin (Sarstedt) for plasma separation and spun for 10min at 4.6 g

The elevated miR-17-5p in turn suppresses MFN2, resulting in diminished mitochondrial fusion, increased fission, and enhanced mitophagy, collectively promoting 5-FU resistance in CRC cells[193]

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