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Studies show that patients losing 510% of body weight may experience changes in their INR (international normalized ratio) if taking warfarin, or altered drug exposure with direct oral anticoagulants

[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Ota Y., Kawaguchi Y., Takagi K., Ichida H., Gono T., Hanaoka M., Higuchi T., Yamanaka H

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PL37 showed a significant analgesic effect in animal models that can reduce neuropathic pain without the possible side effects of opiates

The mixture is then filtered through sterilizing filters (0.22 m) and filled into sterile vials in an aseptic environment