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revealed that inhibiting the 15LOX-2/PEBP1 complex, even without directly targeting 15-LOX, can reduce the production of 15-hydroperoxy-eicosatetraenoyl phosphatidylethanolamine (15-HpETE-PE), thereby effectively suppressing lipid peroxidation and ferroptosis ( in vitro and in vivo by specifically targeting the 15LOX-2/PEBP1 complex, which has become a critical target in ferroptosis research (Dar et al., 2023)

Selenium Deficiency-Induced Pancreatic Pathology Is Associated with Oxidative Stress and Energy Metabolism Disequilibrium

Cell Mol Immunol