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EGF-enriched hydrogels promoted synaptic plasticity under local hypoxia after SCI via downregulated the Fbln5 and Rtl-S3 genes, and upregulated Clcfl , Tgml , and Ptgs2 genes ( 4.3.3 Hydrogel + Peptide A new biomaterial, i.e., self-assembled peptide hydrogel has the advantages of moderate mechanical tension and permeability, low cost, good viscoelasticity, good biocompatibility, low immunogenicity, and being non-inflammatory (Rad-Malekshahi et al., 2016)

demonstrated that patients with aSAH exhibit overactivation of the NLRP3 inflammasome, evidenced by increased expression of NLRP3 and CASP1 in monocytes, along with elevated levels of inflammasome end-products, including IL-1, IL-18, GSDMD, and TF (90)

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Lei X, Zeng G, Zhang Y, Li Q, Zhang J, Bai Z, et al

PMID: 31554935