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,,HutkinsR,WalterJGibsonGRet al.Classifying compounds as prebiotics scientific perspectives and recommendations.2025;22:5470 109

doi: 10.1007/s10803-010-1036-5

15ChalasaniN, FontanaRJ, BonkovskyHL,

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62 Over the years, various combinations of vitamins (B 2 , B 3 , B 12 , C, E, and folic acid) and other compounds with putative mitochondrial antioxidant and bioenergetics properties have been used to treat patients with mitochondrial disease, including LHON, but none with any convincing proof of efficacy