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In the neoadjuvant setting, the TROPION-Breast-04 (NCT06112379) trial will compare the BEGONIA regimen of Dato-DXd with durvalumab against the KEYNOTE-522 regimen in the neoadjuvant setting for patients with stage II-III TNBC or HER2-low disease, with the hope of de-escalating toxicities of chemotherapy in the curative setting

The factual differences are documented, the payment moat is structural, and the proprietary blends are not available elsewhere

However, it should be part of a comprehensive approach that includes diet, hydration, exercise, and medical consultation when needed

Endocrinology 154 (6), 19901998

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