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Previous studies in animal models and in ALS patients showed that injections of ultrahigh-dose methylcobalamin, a naturally occurring form of vitamin B12, could help improve the transmission of nerve signals between the brain and muscles

Orai1 is an essential pore subunit of the CRAC channel

TABLE 5 In vivo Studies Using BALB/c Mice

doi: 10.3390/ijms16010378 8 MurruEMancaCCartaGBanniS

Using IC 50 values and prior knowledge as criteria, we selected 12 out of the 28 predicted drugs (3 FDA-approved non-melanoma anticancer and 9 FDA-approved for other diseases) for experimental validation