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Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways[J]

Meanwhile, increased lipid levels in the TME also exert immunosuppressive effects

It shifts melanin production from darker eumelanin toward lighter phaeomelanin

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4.2 Small molecule compounds to inhibit cuproptosis by targeting mitochondrial respiration and TCA cycle According to the outcome of Tsvetkov et al., the cells with active mitochondrial respiration and high levels of lipoylated TCA enzymes were more sensitive to the Cu-dependent cell death