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In postischemia brains, oxidative stress directs the activation of astrocytes and microglia which brings striking elevation in the inflammatory mediators such as matrix metalloproteases, chemokines, and cytokines and results in the loss of endothelial cell integrity in the brain by upregulating the neutrophil infiltration and cell adhesion molecules

Explain that immunosuppressive therapy is the treatment of choice in clients without HLA-matched donors and/or older than 40 years of age

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Gao D, Wu J, Wu Y-T, Du F, Aroh C, Yan N, et al