glutathione-synthesizing enzymes Glutathione synthetase Glutathione Metabolism and Its Implications

RSC Adv

With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy

Meanwhile, the cell cycle could be blocked by the addition of GSSG, also indicating the participation of GSH in cell proliferation [64]

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