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In summary, the treatment of PD has entered an era of integrated management characterized by the synergy between pharmacological and non-pharmacological approaches, equal emphasis on symptomatic and causative treatment, and consideration of both present and future needs

They have glutamate receptors that take up excess glutamate in the synapse as a way to regulate the signaling process

Altered mitochondrial morphology can, in turn, affect cellular function by disrupting the Krebs cycle and reducing mitochondrial calcium uptake (Zhang et al., 2013

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