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2.5 Immune microenvironment With the continuous study of tumor immunity, some researchers have proposed several immune subtypes of tumors based on the histological characteristics of tumors ( Figure 2 )

Indeed, recent elegant studies in humans and collecting duct cell lines showed that IGF-1 regulates sodium reabsorption in the distal nephron by activation of the IGF-1R, which results in upregulation of the ENaC [25, 26]