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Androgens withdrawal promotes the loss of vascular integrity, pointing to the possibility that the vascular component of the prostate microenvironment can be an important component of treatment-induced therapy resistance since some experiments have shown a transient loss of vascular integrity that is recovered after a time of androgen deprivation [109] The changes in vascularization make the environment hypoxic and acidic [110]

This study adheres to the SAGER guidelines

However, high expression of CD206 illustrates that AMs express a hybrid phenotype

an 18-day double-blind, randomized, placebo-controlled, crossover study with two 48-h pharmacokinetic interventions separated by a 10-day washout